Spent coffee grounds (SCGs) are an abundant agro-industrial residue with high potential as a source of phenolic compounds and proteins. This study evaluated the extraction of these value-added fractions using hydrophilic and hydrophobic eutectic solvents, applied either alone or combined with enzyme-assisted extraction. A total of 31 hydrophobic eutectic solvents (HESs), nine hydrophilic deep eutectic solvents (DESs), and five conventional solvents were screened for phenolic recovery. Extraction