Mechanism of Astragaloside IV Against Cerebral Ischemia–Reperfusion Injury: Inhibiting Neuronal Apoptosis via the CytC/Apaf-1 Mitochondrial Pathway
Tongtong He·Xiaofei JIN·Xiaohong Joe Zhou·Ping Gao·Zhenyi Liu·Y. S. Zhao·Hua Liang·Weijuan Gao·Zhe Zhang
Background: Neuronal apoptosis is the core pathological mechanism of cerebral ischemic–reperfusion injury (CIRI); although Astragaloside IV (AS-IV) has demonstrated neuroprotective activity against CIRI, its specific molecular mechanisms underlying the regulation of this apoptosis-related pathway remain to be systematically elucidated. Methods: We establish an in vivo model of middle cerebral artery occlusion/reperfusion (MCAO/R) in rats and an in vitro model of oxygen–glucose deprivation/reperf