Low-density neutrophils preferentially infiltrate the skin compared to conventional neutrophils in an experimental psoriasis model
Alicja Dziadowiec·Joanna Cichy·Monika Kapińska-Mrowiecka·Joanna Skrzeczyńska-Moncznik·Ivan Sinkevich·Ewa Werner·Patrycja Kwiecińska
Neutrophils infiltrate lesional skin robustly in individuals with psoriasis. However, their role in chronically inflamed skin-particularly in terms of phenotypic and functional diversity-remains poorly understood. In this study, we investigated the functional potential of 2 distinct circulating neutrophil populations-conventional, polymorphonuclear neutrophils (cNeu) and low-density neutrophils (LDNeu)-to infiltrate lesional skin in an experimental model of psoriasis. We found that, similar to h