Divergent pathogenesis of two Chinese Crimean–Congo hemorrhagic fever viruses in cynomolgus macaques
Juhong Rao·Chao Shan·Mengdi Wang·Yan Peng·Miaoyu Chen·Yanfeng Yao·Hang Liu·Xi Wang·Tingting Jiang·Fei Deng·Xue Hu·Ge Gao·Zhe Hu·Jianfeng Liu·Zhiming Yuan·Zheng Zhang
These findings demonstrate that Chinese isolates exhibit distinct clinical, virological, and pathological phenotypes in cynomolgus macaques, underscoring the value of this model for recapitulating aspects of CCHF disease, for pathogenesis research, and for evaluating medical countermeasures.