NNew Phytologist3/26/2026

Guard cell photorespiration controls stomata behavior and development

Photorespiration is traditionally viewed as a limitation to photosynthetic efficiency. However, it is mandatory for safeguarding the Calvin-Benson-Bassham cycle from inhibitory byproducts through Rubisco-mediated oxidative misfire and is tightly integrated with primary metabolism. Whether photorespiratory metabolism directly regulates guard cell function and stomatal behavior remains a matter of intense debate. We manipulated the photorespiration-restricted pathway entry enzyme 2-phosphoglycolat