Fabrication of Robust Poly( l -lactic acid) Nanofiber Yarns Loaded with Curcumin@ZIF-8 Nanoparticles for Sustained Drug Release in Biomedical Applications

Electrospun nanofiber yarns loaded with drugs or bioadditives combine nanobionic structures with enhanced bioactivities, showing great promise for advanced biomedical textiles, but are hindered by burst release, short release periods, and poor mechanical properties. This study designed a hierarchical drug encapsulation yarn system. Curcumin (Cur) was first encapsulated into zeolitic imidazolate framework-8 (ZIF-8) to generate Cur@ZIF-8 nanoparticles, which were then loaded into poly(l-lactic aci