Integrated whole-genome resequencing and mRNA-miRNA analysis reveals selection signals and regulatory networks of antipyretic effect variation in Morus alba var. multicaulis

Lusang (Morus alba var. multicaulis) represents both the inception and paradigm of artificial cultivation and breeding of mulberry (Morus spp.) in China, marking the onset of mulberry domestication. However, the genetic structure underlying this domestication process remains poorly understood, and no reports to date have described the selection signals and their candidate genes, or mRNA–miRNA regulatory networks associated with the pharmacological traits of Lusang. In this study, we performed wh