Salbutamol sulfate was analyzed using a straightforward, expeditious, and precise spectrophotometric approach. This method enabled the rapid and precise quantification of salbutamol sulfate within complex samples.in this method Salbutamol sulfate is coupled with a diazotized p-methoxy aniline reagent in an alkaline medium to form stable and water- soluble yellow azo dye . The resulting compound exhibited maximum absorption at 426 nm The method follows Beer's law was over the concentration range