Mechanism of arbutin in metabolic dysfunction-associated fatty liver disease based on multi-omics research

Gut microbiota regulation is a key strategy for treating metabolic dysfunction-associated fatty liver disease (MAFLD). Arbutin (ARB) is a natural hydroquinone active agent with anti-inflammatory and antioxidant effects, as well as regulatory effects on the gut microbiota. However, its therapeutic effect on MAFLD and the responsible mechanisms remain unclear. This study explored the therapeutic effect and mechanisms of ARB in MAFLD treatment. High-fat diet (HFD)-fed mice served as the in vivo MAF