The RNA molecule or the transcription process: which is critical in the regulation of fbp1 gene activation mediated by metabolic stress-induced lncRNA (mlonRNA) in fission yeast

Recent studies have revealed important roles of promoter-associated long noncoding RNAs (lncRNAs) in the regulation of adjacent genes. One of the first such RNA identified is the metabolic stress-induced lncRNA (mlonRNA) in fission yeast, which is involved in the activation of the fbp1 gene under glucose starvation. Whether this promoter-associated lncRNAs function through the RNA molecule itself or through the act of transcription remains a fundamental unresolved question. We here discriminate