Engineering of Corynebacterium glutamicum for the enhanced production of optically pure (meso)-2,3-butanediol

2,3-Butanediol (2,3-BDO) is a versatile platform chemical with diverse applications in cosmetics, pharmaceuticals, agricultural and food manufacturing. Among its stereoisomers, optically pure (meso)-2,3-BDO is particularly valuable; however, achieving high titers with stereoselectivity remains challenging in conventional hosts due to byproduct formation, low tolerance, and plasmid instability. In this study, we established Corynebacterium glutamicum as an efficient and robust chassis for the ind