Skull bone marrow immunity in brain health and disease: mechanisms and models

The skull bone marrow (sBM) is a hematopoietic site intimately connected to the dura mater-the outermost layer of the meninges that surround the central nervous system (CNS)-via vascular channels that enable trafficking of immune cells and sampling of cerebrospinal fluid. sBM-derived cells directly access the dura under homeostasis and, following pathology, can infiltrate the CNS, contributing to immune surveillance, neuroinflammation, and disease outcomes. Here, we discuss the anatomical and fu