PSC-UC neoplasia associates with transmissible microbiota-dependent inflammation and secondary BA deficiency. Controlled restoration of BA-transforming microbial functions, rather than indiscriminate secondary BA replacement, is a rational translational direction.
Dysbiotic microbiota trigger colitis-associated colorectal cancer and imprint a distinctive bile acid profile in a PSC-IBD model
Muyiwa Awoniyi·R Balfour Sartor·Josue Hernandez·Qijun Yang·Nicholas Evans·Ina Nemet·Billy Ngo·Deniz Coskuner·Julie Y. Zhou·Morgan Farmer·Lianyong Su·Huiping Zhou·J. Roach·T. S. Stappenbeck·Mohamed El Hag