Rapid quantitative bioanalysis using LC-HRIM-QTOFMS with flexible sample delivery and variable traveling wave profiles

Incorporating an additional high-resolution ion mobility (HRIM) dimension can increase throughput and deliver results with high sensitivity and minimal ion suppression for bioanalytical LC-MS applications. However, the lengthy HRIM separation step conventionally comes at the cost of less data points per LC peak and a reduced working range, compromising quantification goals. This work addresses these challenges by using an alternative method for sample delivery and HRIM traveling wave profiles to