A ketogenic diet reduces hepatic alcohol metabolism and alcohol consumption in rats
Sophie K. Elvig·Leandro F. Vendruscolo·Michael Michaelides·Robert J. Pawlosky·Corinde E. Wiers·Adrienne McGinn·M. Todd King·Xinyi Li·George F. Koob·Juan L. Gomez·Luis Gonzalez·Nora D. Volkow·Janaina C. M. Vendruscolo·Bin Gao·Bryan Mackowiak
Previous work showed that rats that were exposed to a high-fat, low-carbohydrate/protein ketogenic diet (KD) exhibited elevated blood alcohol levels following alcohol exposure compared with rats fed regular chow. Additionally, the administration of a KD prior to alcohol exposure (i.e., a history of KD) reduced alcohol consumption in alcohol-dependent rats that were no longer on the diet. In the present study, we investigated the mechanisms by which a KD alters alcohol metabolism and tested wheth