Genetic background modulates zoliflodacin and gepotidacin cross-resistance and fitness in Neisseria gonorrhoeae
Aditi Mukherjee·Yonatan H. Grad·Samantha G. Palace·David Helekal·Apabrita Ayan Das·Sofia O P Blomqvist
Genetic background modulated the phenotypic effects of a zoliflodacin-resistance determinant on fitness and cross-resistance to gepotidacin. These findings inform strategies for introducing the new topoisomerase inhibitors into clinical use and for surveillance of resistance.