Single-cell hepatitis B sequencing reveals distinct viral infection events consistent with superinfection
Monika Mani·Ashwin Balagopal·Mark Sulkowski·Alessandro Olivo·Giulia Belluccini·Richard K. Sterling·Mark Anderson·Gavin Cloherty·Chloe L Thio·Steven J. Clipman·Justin R Bailey·Ruy M. Ribeiro
Taken together, our findings demonstrate that individual hepatocytes may harbor multiple, transcriptionally active HBV cccDNA molecules, which likely arose from distinct infection events.