These findings uncover a multifaceted role for IL-6 in shaping tumour-intrinsic, microenvironmental and macroenvironmental features, revealing novel molecular mechanisms and potential therapeutic vulnerabilities in iCCA.
Molecular and cellular consequences of tumour-autonomous IL-6 signalling in intrahepatic cholangiocarcinoma
Virag Gehl·Jesper B Andersen·Niklas K. Björkström·Supaporn Yangngam·Achilleas Fardellas·Magdalena Rogalska·Colm J. O’Rourke·J U Marquardt·Dan Hogdall·Blanca I Aldana·Martin Cornillet·Orestis Nousias