Heterogeneity in inflammatory responses to endotoxin at the fetomaternal interface
Vineeth Mahajan·Ananth Kumar Kammala·Tilu Jain Thomas·Isidore Mushimiyimana·Madhuri Tatiparthy·Emmanuel Amabebe·Ramkumar Menon·Lauren Richardson
The fetomaternal interface (FMi), comprising fetal chorionic trophoblast cells (CTCs) and maternal decidual stromal cells (DECs), plays a critical role in providing immune tolerance during pregnancy. Intrauterine inflammation is major trigger of adverse outcomes such as preterm birth, yet the cell-specific inflammatory responses at the FMi -; poorly defined. We investigated differential inflammatory responses of fetal and maternal cell populations at the FMi upon exposure to endotoxin (lipopolys