HDAC7 is a key factor for the germinal center reaction and its underexpression is associated with DLBCL prognosis
Ainara Meler·Maribel Parra·M Gusi-Vives·Balázs Győrffy·Alberto Del Monte-Monge·Alba Azagra·Olga Collazo·Gaël Roué·Oriol de Barrios·Javier Melchor·Sergio Roa·Jose Ignacio Martin-Subero·Miriam Verdú-Bou·José-Tomás Navarro·Almudena R. Ramiro
Histone deacetylase HDAC7 is required for early B cell development and governs the acquisition of B cell progenitors gene identity. Its role in mature B cell biology and associated malignancies is unknown. Here, by using a conditional mouse model for specific deletion in activated B cells, we demonstrate that HDAC7 is essential for the formation of germinal centers (GC). HDAC7 deficiency results in the generation of aberrant GCB cells, diminished class switch recombination (CSR) and plasma cell