Nucleotide-binding, leucine-rich repeat (NLR) receptors are widespread intracellular immune sensors across kingdoms. Plant G10-type coiled-coil (CCG10)-NLRs constitute a distinct phylogenetic clade that remains poorly characterized. Here, we identified a gain-of-function mutant of wheat autoimmunity 3 (WAI3GOF), which encodes a constitutively active CCG10-NLR resulting from a residue substitution in the leucine-rich repeat (LRR) domain. Cryo-electron microscopy (
An activated wheat CCG10-NLR immune receptor forms an octameric resistosome
Guanghao Guo·Jonathan D.G. Jones·Yikun Hou·Sophien Kamoun·G Li·Muniyandi Selvaraj·Gaojie Wang·Zhiying Chu·Zhiyong Liu·Qiuhong Wu·Miaomiao Li·He Zhao·Lei Lu·Yue Zhang·Huaizhi Zhang·Yongxing Chen·Professor Jian Lu·Chenchen Hu·Ping Lu·Keyu Zhu·Lingli Dong·Hongkui Fu·Xue Lyu·Baoge Huang·Xuejia Cui·Chao Wang·Kaihong Bai