Inflammatory protein profiling in immune cells identifies molecular signatures for enhanced diagnostic precision in psoriatic arthritis

Psoriatic arthritis (PsA) lacks reliable biomarkers to support early diagnosis and disease stratification. This study aimed to identify protein signatures associated with PsA and develop a clinically relevant model integrating molecular and clinical features. We conducted a cross-sectional study including 143 patients with PsA and 101 controls across three cohorts. The exploratory cohort included 77 patients with PsA and 50 symptomatic controls without inflammatory disease. Two independent cohor