Estrogen receptor β deficiency increases susceptibility to sepsis through metabolic reprogramming-induced macrophage pyroptosis
Yanrong Zhu·Yue Dai·Wanyi Zhang·Pengxiang Guo·Yilei Guo·Zhifeng Wei·Yue He·Gang Li·Lei Gao·Jing Zhang·Haochang Lin·Wenjie Zhang·Yufeng Xia
Understanding susceptibility factors of sepsis is crucial for early diagnosis and development of personalized treatment strategies. However, the genetic determinants for initiation and progression of sepsis remain unclear. Here, we showed that the expression levels of estrogen receptor (ER) β are significantly reduced in the peripheral blood of sepsis patients, which were negatively correlated with disease severity. The results from human samples and experimental animals demonstrated that ERβ de