Neoadjuvant systemic immunotherapy for skin cancers

Neoadjuvant treatment for skin cancer refers to treatment given to resectable tumors before surgery with the primary aim of improving prognostic outcomes. In addition, it may downstage the tumor to decrease surgical morbidity, and may de-escalate adjuvant therapies in cases of complete response. This in-depth review discusses the principles of neoadjuvant immunotherapy for cutaneous melanoma and invasive cutaneous squamous cell carcinoma (CSCC). Lessons learned from prospective neoadjuvant syste