High dietary fiber is associated with improved outcomes in patients with melanoma and sarcoma treated with immunotherapy regardless of gut microbiome dysbiosis and social vulnerability
Brittany C. Fields·A. T. Holder·Jennifer A. Wargo·Manoj Chelvanambi·Russell G. Witt·Ashish Damania·Kai Jiang·Emily Z. Keung·Christina L. Roland·Yi‐Ju Jill Chiang·Carrie Daniel·Nadim Ajami·Xiaotao Zhang·Elise Nassif‐Haddad·Christine B. Peterson·Raymond Traweek
Increased social vulnerability was associated with a less favorable gut microbiome composition but not worse OS among melanoma and sarcoma patients treated with ICB. Consistent with prior findings, high dietary fiber intake emerged as a potentially modifiable pathway to improve outcomes in patients initiating ICB, particularly those with increased SVI.