Pathogen characteristics are key determinants of distinct host response phenotypes of sepsis
Rishi Chanderraj·Pratik Sinha·Kathleen A. Stringer·Mohamad Hakam Tiba·Kale S. Bongers·Sunny S. Lou·Robert P. Dickson·Debra Foster·Mark D. Adame·Carolyn S. Calfee·Ying He·Matthew M. Churpek·V. Eric Kerschberger·Mark Nuppnau·Michael W. Sjoding·Brian Bartek·Sandhya Tripathi·John A. Kellum
BACKGROUNDSepsis encompasses considerable biological and clinical heterogeneity. Previously, 2 phenotypes ("hyperinflammatory" and "hypoinflammatory") have been consistently identified within sepsis via latent class analysis. These phenotypes differ in their biological features, clinical outcomes, and therapeutic responses to interventions. Prior studies of sepsis heterogeneity have focused primarily on the host response. Here, we investigate the potential influence of the causative pathogen on