FGF family in health and disease
Xiaoyu Liu·Zhengwei Huang·Xuchen Hu·Bo Feng·Qiaoqiao Jin·Meiling Jing·Pengfei Zhang·Yueyi Yang·Chenguang Niu
Fibroblast growth factors (FGFs) form an evolutionarily conserved signaling system that governs embryonic patterning, tissue regeneration, and systemic metabolic homeostasis. Through coordinated interactions with fibroblast growth factor receptors (FGFRs) and context-specific cofactors, FGF signaling enables precise spatial and temporal control of cellular fate and interorgan communication. While canonical FGFs coordinate local tissue dynamics, endocrine members like FGF19, FGF21, and FGF23 func