Polyurethane nanofibrous scaffolds for wound repair: from electrospinning fabrication to biological performance evaluation

This study presents the electrospinning fabrication of thermoplastic polyurethane (TPU) nanofibrous scaffolds with two fiber architectures; randomly oriented and unidirectionally aligned incorporating olive oil and copper oxide nanoparticles (CuO NPs) to enhance biomedical performance. Both scaffold types exhibited robust antibacterial activity: randomly oriented TPU/CuO mats produced inhibition zones of 33.0 mm against Staphylococcus aureus and 19.46 mm against Escherichia coli, whereas aligned