Background: Postoperative sore throat (POST) is a frequent and distressing complication after tracheal intubation for general anesthesia, with reported incidence varying widely depending on definitions and populations. Pharmacologic nebulization prior to induction is an attractive, low-risk, topical approach to reduce mucosal inflammation and nociception. Objective: To evaluate and compare the efficacy of preoperative nebulized dexmedetomidine, ketamine, and magnesium sulphate in preventing POST