Bilateral Theta-Burst Stimulation of Dorsolateral Prefrontal Cortex Regions for Late-Life Depression: A Randomized, Sham-Controlled Clinical Trial
Leandro Valiengo·André Russowsky Brunoni·JF Silva·Wagner F. Gattaz·Bianca Silva Pinto·Júlia Cunha Loureiro·Orestes Vicente Forlenza·Valquíria Aparecida da Silva·Renata Aparecida da Rocha Vaughan·Bruna Bariani Teixeira·Maíra Pinheiro Maux Lessa·Rafael Garcia Benatti·Roberta de Arruda Mendes Pereira Fiuza Dini Mattar·Luara Cristina Tort·Pedro Sudbrack Oliveira·Matthias Luethi·Lisiane Martins·Leonardo Afonso Santos·F. Padberg
The active TBS group did not have a statistically significant greater reduction in HAM-D scores compared to the sham group at week 6. By week 12, however, active TBS was superior to sham stimulation in reducing depressive symptoms in patients with late-life depression, suggesting TBS as a possible treatment option for this population.