NIK-driven IL-23 production by myeloid cells is a key factor in the development of autoimmune inflammation
Nishada Shakunty Ramphal·A Waisman·Tommy Regen·Tobias Bopp·B. Becher·Sinduya Krishnarajah·Ilaria Palagi·Frederike Westermann·Rebecca Jasser·Xinyuan Liu·Matthias Klein·Alma N. Mohebiany
NIK (Map3k14) is a central regulator of noncanonical NF-κB signaling and immune homeostasis. Mutations in this kinase are linked to autoimmune disorders, including multiple sclerosis (MS). Both germline and T cell-specific deletion of NIK had been demonstrated previously to be associated with resistance to developing experimental autoimmune encephalomyelitis (EAE), an animal model for MS. In this study, we show that NIK expression by circulating myeloid cells is crucial for EAE development. Mech