Colonic FMT is a more effective delivery route than nasogastric administration. Clinical response is driven by the engraftment of immunomodulatory bacteria that restore a healthy host-microbe dialogue, providing rationale for developing targeted microbial therapeutics.
Mechanistic insights into fecal microbiota transplantation for the treatment of ulcerative colitis: analysis of the STOP-Colitis trial
Mohammed Nabil Quraishi·Tariq H Iqbal·Christopher Quince·Vaios Svolos·Richard Hansen·Ailsa L Hart·Mehmet Yalchin·Natalie J Ives·Nicola Crees·Victoria McCune·Ben Nichols·Andrew D Beggs·Susan E Manzoor·Manjinder Kaur·Caroline Kerbiriou·Shrushma Loi·Laura Magill·Richard Horniblow·Catherine A Moakes·Jonathan Segal·Ye H Oo·Naveen Sharma·Daniel R Gaya·Jonathan Mathers·Joshua Quick·Claire McMurray·Konstantinos Gerasimidis·Sebastien Raguideau·Christel McMullan·Claire Blackwell·Peter Hawkey·Nicholas J Loman·Samuel Nicholls