In this study, a dithizone (Di-DHZ) derivative was synthesized, characterized by UV-Vis analysis, used as an ionophore in a potentiometric sensor, and selectively used in Pb2+ ion detection. Di-DHZ compound was synthesized by the reaction of dithizone and iodine in dichloromethane. In UV analyses, distinct bathochromic shifts and complex formations were observed, indicating the formation of dithizone (Di-DHZ). To test the effectiveness of potentiometric synchronization, a PVC membrane containing various plasticizers (DBP, DEHA, BEHS) and KTpClPB as additives was developed. Then, Di-DHZ was incorporated into the membrane. The developed sensor exhibited a Nernstian slope of -27.64 mV/decade, a wide linear range (1.0×10⁻⁵–1.0×10⁻¹ mol/L), and a correlation coefficient of R² = 0.9995. The limit of detection (LOD) and limit of quantification (LOQ) were calculated as 7.59×10⁻9 mol/L and 5.59×10⁻8 LOQ, respectively. The electrode exhibited high selectivity towards Pb²⁺ among interfering ions, including Cd²⁺, Mg²⁺, and Li⁺. A stable potential response was observed across the pH range 4.0-8.0, with optimal performance at near-neutral conditions. The applicability of the sensor was confirmed through EDTA titration and recovery studies using real samples (peach, apricot, and tap water), providing satisfactory recovery rates (93.5-99.6%) and low relative standard deviations (RSD < 0.02%). The experimental results showed that the developed Di-DHZ-based potentiometric sensor provides reliable, selective, and accurate detection of lead ions across various solution environments.