This study examines the impact of health information exchange (HIE) participation on hospital performance in the United States, focusing on profitability, efficiency, and quality. Analyzing data from 3,294 hospitals over 3 years (2014–2016) and using multiple regression models, the results showed a positive association between HIE participation and improved performance. HIE membership is linked to increased profitability, enhanced efficiency, and certain quality enhancements, particularly in lar