Active Zone Maturation Controls Presynaptic Output and Release Mode and Is Regulated by Neuronal Activity

Active Zone Maturation Controls Presynaptic Output and Release Mode and Is Regulated by Neuronal Activity Akbergenova, Yulia; Matthias, Jessica; Makeyeva, Sofya; Littleton, J Troy Synapse formation requires the accumulation of cytomatrix proteins and voltage-gated Ca2+ channels (VGCCs) at presynaptic active zones (AZs). At Drosophila melanogaster larval neuromuscular junctions, a sequential process of AZ maturation is observed, with initial incorporation of early scaffolds followed by arrival of