immunology-and-allergy

Researchers with the James P. Allison Institute(tm) at The University of Texas MD Anderson Cancer Center have discovered a new gene expression signature within tumors that can help identify patients with metastatic castration-resistant prostate cancer (mCRPC) who are more likely to experience lasting benefits from combined immunotherapy treatment.

Phase 2 trial investigated the effectiveness of pembrolizumab (Keytruda) in rare cancers Overall responses were modest, but analysis showed new potential biomarkers beyond the current genomic markers of response These biomarkers could expand benefits of immunotherapy to patients who previously would not have been expected to respond A new study in Cell Reports Medicine from researchers at The Uni…

Nature Communications, Published online: 21 May 2026; doi:10.1038/s41467-026-73280-0 The study shows that E. coli infection disrupts copper balance by inducing CTR2 through acetylated mitochondrial MDH2, triggering cuproptosis and liver injury, and suggests that targeting this pathway may help limit infection-associated damage.

Conflict and aid cuts are hampering the fight against an outbreak of the deadly virus centred in the Democratic Republic of the Congo The Democratic Republic of the Congo has faced the deadly threat of Ebola 16 times since the virus was discovered there in 1976, with a 2018-20 outbreak killing almost 2,300 people. On Sunday, the World Health Organization declared the 17th outbreak to be a public …

Scientists found that blocking a protein best known for its role in asthma enhances cancer immunotherapy in preclinical models.

A new study in Cell Reports Medicine from researchers at The University of Texas MD Anderson Cancer Center identified key features that may help predict which types of rare cancers are likely to respond to immunotherapy.

A decade after Ebola vaccines changed outbreak response, a new epidemic in central Africa is caused by a strain the world never fully prepared for

Nature Medicine, Published online: 20 May 2026; doi:10.1038/s41591-026-04384-9 The authors examine the vaccine landscape through two key areas of research and development—expanding target populations, and emerging vaccine technologies—and discuss cross-cutting issues, including the societal value of vaccines, funding and access, and regional manufacturing.

Nature Medicine, Published online: 20 May 2026; doi:10.1038/s41591-026-04374-x Women are now at the very center of the global cancer control agenda, but there are major challenges ahead.

A new genetic study suggests that specific gut bacteria may influence the risk of postpartum depression. By analyzing DNA variations and blood metabolites, scientists mapped how microbial communities might alter cholesterol and cellular switches to affect maternal mental health.

BackgroundSystemic lupus erythematosus (SLE) and IgA nephropathy (IgAN) are immune-mediated renal disorders characterized by aberrant B-cell activation. While SLE shows a striking female predominance, IgAN is more prevalent in males; nonetheless, both conditions typically peak the during reproductive years. Their pathogenesis involves distinct molecular drivers: SLE is mediated by specific autoan…

A University of Nebraska-Lincoln research effort aims to strengthen defenses against future flu pandemics by advancing a vaccine designed to provide strong, durable immunity against multiple high

UK scientists find tocilizumab, used for rheumatoid arthritis, may help antidepressant-resistant patients Immunotherapy could be used to treat depression among patients who have not responded to conventional antidepressants, according to the results of an early clinical trial. Researchers at the University of Bristol investigated whether tocilizumab, an anti-inflammatory drug commonly used for im…

Nature Immunology, Published online: 20 May 2026; doi:10.1038/s41590-026-02554-y Author Correction: The differentiation and function of heterogeneous thymic dendritic cell subsets require signals provided by distinct thymocyte cell types

Rare Bundibugyo strain of infectious disease, detected in DR Congo and Uganda, has no approved vaccine or treatment

The response to the current wave of the disease, which has caused 139 deaths in central Africa to date, has been hampered by security concerns Doses of the “most promising” potential vaccine against the Bundibugyo virus that is causing an Ebola outbreak in central Africa will not be available for six to nine months, the World Health Organization said on Wednesday, as the number of suspected cases…

Event Details Sathyabama Institute of Science and Technology, Chennai is organising a Training Program on ‘BIOMEDICAL TECHNIQUES IN MODERN BIOLOGY’ Sponsored by Department of Health Research (ICMR-DHR) from 29 June 2026 to 06 August 2026 at ‘International Research Center of Sathyabama Institute of Science and Technology, Chennai through physical mode. This workshop provides hands-on training in b…

With real-time feedback, people can learn to turn on a part of the brain that helps rev up the immune system, new data show.

Nature Immunology, Published online: 20 May 2026; doi:10.1038/s41590-026-02512-8 Dong, Ray et al. identify salt-inducible kinases (SIKs) as potential drivers of T cell dysfunction in the immunosuppressive microenvironment of ovarian cancer.