Fabiana Corsi-Zuelli
4/10/2026
immune-systemmedicinemental-healthpsychosis
BackgroundNegative symptoms are a core feature of psychotic disorders, evident from the first episode of psychosis (FEP), and are strongly associated with poor functional outcomes. Increasing evidence suggests that immune dysregulation may contribute to negative symptom expression in FEP individuals; however, findings remain heterogeneous. This systematic review aimed to synthesise recent evidenc…