Stroke

Cerebral venous thrombosis is a rare stroke type that primarily affects younger women. Contemporary large international efforts have improved our understanding of the natural history and management of this rare disease, yet important evidence gaps persist across the disease continuum. Management of cerebral venous thrombosis can be conceptualized into multiple phases: acute management, primary th…

URL: https://www.clinicaltrials.gov; Unique identifier: NCT03876457.

Stroke remains a leading cause of death and disability worldwide. In response, many governments have developed stroke policies emphasizing prevention, early detection, timely treatment, and rehabilitation. However, the implementation of those strategies remains uneven, challenged by fragmented health systems, unequal access to care, and resource constraints. Digital health tools provide robust so…

Globally, stroke prevalence rates stagnated in the working-age population, while DALY and death rates declined during the observation period; both patterns are expected to persist through 2040. However, local divergences and subtype paradoxes persist. Policies must be context-specific across prevention, acute care, and rehabilitation.

This meta-analysis provides updated estimates of stroke after bioprosthetic AVR for AS, capturing risk beyond the early periprocedural period. Future studies should investigate the causes of long-term stroke post-AVR, the effects of different antithrombotic therapies on the risk of stroke, as well as the potential impact of these procedures on short and long-term cognitive function.

We show that IL-1Ra is cleaved by plasmin, and its administration during thrombolysis worsens outcomes poststroke. These studies confirm a negative interaction between the 2 drugs, which can be prevented by tPA preceding IL-1Ra treatment. The findings raise broader concerns about how tPA may interfere with other neuroprotective treatments.

URL: https://www.clinicaltrials.gov; Unique identifier: NCT05163210.

Women face a higher lifetime risk of stroke and dementia than men, yet prevention strategies are not optimally implemented for women. Midlife (ages 40-65) represents a critical yet underused life stage window for prevention. This period encompasses the menopausal transition, when hormonal, metabolic, vascular, and neurological changes converge. Despite this, women remain underrepresented in strok…

URL: https://www.clinicaltrials.gov; Unique identifier: NCT01934725.

Over a third of young adults with CIS had thrombophilia deviations at admission although high-risk thrombophilia results remained rare. Screening may be considered in young patients with CIS with a history of venous thromboembolism, physical inactivity, and low hemoglobin or HDL-cholesterol.