The Journal of Pediatrics

Neurofibromatosis 1-associated optic pathway gliomas (OPGs) may co-occur with central precocious puberty (CPP). Using large language model-based data analysis from 2 NF centers, we compared OPGs in children with NF1, with and without CPP. CPP was associated with hypothalamic involvement, poorer vision, and a higher likelihood of OPG treatment.

Extracorporeal membrane oxygenation (ECMO) is only available in specialized medical centers. We conducted a geospatial analysis and found state- and region-level variation in the supply of ECMO centers and the number of children who had access to ECMO. These findings may help target areas for the development of new ECMO programs.

These findings highlight the broader protective effect of nirsevimab on complications of respiratory tract infections in infants.

This multi-institutional, natural language processing-based analysis of 273 children with neurofibromatosis 1-associated optic pathway gliomas examines the impact of ancestral background on clinical presentation and progression. We report that White children had higher OPG prevalence than Black or Asian children, but clinical features and outcomes did not differ across groups.