Clinical Infectious Diseases

The study found that younger adults (30+ YoA) with certain comorbidities have a higher HZ risk than immunocompetent 50-59 YoA adults.

Advances in antiretroviral therapy have substantially increased life expectancy among people with human immunodeficiency virus in the United States, leading to an older population with a growing burden of chronic noninfectious comorbid conditions. In parallel, the delivery of primary care to an older population is increasingly complex, often taking infectious diseases (ID) specialists outside the…

Since the beginning of the human immunodeficiency virus (HIV) epidemic in the United States, infectious disease (ID) specialists have provided HIV and primary care for people with HIV. As patients often now have controlled HIV but increasing comorbidities, some advocate that ID specialists shift away from HIV primary care. However, shortages of primary care providers and non-ID-trained HIV provid…

Our findings demonstrate that modifiable clinical care practices shape the developing microbiome of preterm infants and contribute to geographic differences in BSI epidemiology. The skin microbiome represents a potentially significant risk factor for invasive infection. Further work to clarify how specific clinical practices influence pathogen colonization may inform strategies to reduce BSI inci…

Almost a third of the entire VS rate was from ADAP clients, despite ADAP serving less than 25% of PWH. A much higher proportion of ADAP clients achieved VS, compared to PWH. AIDS Drug Assistance Programs' impact is not due to ADAP clients being over represented among PWH with reported VLs. AIDS Drug Assistance Program does not directly receive any federal Ending the HIV Epidemic (EHE) Initiative …

After the implementation of doxy-PEP, syphilis diagnoses declined dramatically, including among cisgender women. This decline has not affected syphilis in pregnant persons or CS.

Though apparently short-lived, detectable asymptomatic P. ovale parasitemia frequently recurs. The proportion of Po recurrences attributable to relapse in this setting remains unclear.

Roughly half of PWTS were recommended TB therapy. This prevalence supports treating most PWTS when multimodal testing and repeated clinical evaluations are infeasible. However, given low observed mortality, some people with low-risk characteristics and negative results on other widely available diagnostic tests could safely defer treatment with clinical follow-up.

Little is known about antibiotic use and antimicrobial resistance among people who inject drugs and people experiencing homelessness. Here, we identify key antibiotic stewardship challenges unique to this important patient population and outline concrete street stewardship interventions to better understand and/or ameliorate them.