Supply chain management systems, healthcare, payments, businesses, the IoT voting systems, and countless more utilize its high security and transparency to protect a variety of digital assets from In order to demonstrate how blockchain technology functions overall, this chapter also provides a number of examples of its use and the difficulties associated with implementing it in other sectors. Virtual healthcare stands to benefit greatly from the revolutionary potential offered by the coming together of metaverse technology, blockchain, AI and ML. In order to provide safe, individualized, and easily accessible healthcare, this chapter delves at the potential of integrating AI and ML with blockchain-based systems in metaverse settings. In order to achieve trustworthy, scalable, and patient-centered virtual healthcare in metaverse ecosystems, this chapter finishes by outlining research directions and policy considerations.