ABSTRACT The classical medical paradigm defines health primarily as a negative state: the absence of detectable pathology or structural disease. This binary framework inherently fails to capture the dynamic, pre-clinical deterioration of human vitality. Utilizing the High Entropy Predictive Organization Efficiency (HEPOE Theory) framework, this paper proposes a epistemological shift, redefining human health through the laws of Biological Thermodynamics and Information Physics. Health is formally modeled not as a static baseline, but as a continuous state of Bioenergetic Solvency, the structural capacity of an organism to efficiently dissipate informational heat, continuously resynthesize Adenosine Triphosphate (ATP), and manage the entropic chaos of the environment (H(E)) without triggering systemic thermal throttling. By shifting the clinical focus from peripheral symptom management to central entropic dissipation and systemic friction (Ω), we propose a new, quantifiable metric for vitality, establishing thermodynamic resilience as the ultimate biological vital sign. Keywords: HEPOE Framework. Bioenergetic Solvency. Entropic Management. Thermodynamic Resilience. Predictive Insolvency. Systemic Thermal Throttling. Allostatic Load. Preventive Medicine. Information Physics.