Multiomic profiling of LKB1 loss of expression in breast cancer

The tumour suppressor LKB1 (STK11) is implicated in diverse cancers, yet its transcriptomic role in breast cancer remains poorly defined. Here, we integrate bulk-tumour genomic analysis of the METABRIC cohort, CRISPR-Cas9-mediated STK11 knockout in human breast cancer cell lines, single-cell RNA sequencing of patient tumours, and a novel Lkb1 murine model to characterise LKB1-dependent transcriptomic programmes across breast cancer subtypes. We discovered that the loss of STK11 induced divergent