A chiral multiporphyrin receptor was prepared by covalent attachment of six zinc tetraphenylporphyrin units to a biotin[6]uril sulfoxide scaffold through flexible amide-linked side chains. In non-coordinating solvents, the conjugate adopts a propeller-like, C3-symmetric conformation in which three π–π-stacked porphyrin pairs are arranged helically around the chiral macrocyclic core, producing a strong exciton-coupled circular dichroism (CD) response in the Soret region. Addition of methanol as a