Physical exercise as a precision strategy for targeted PINK1 recruitment- a mechanistic review

PTEN-induced kinase 1 (PINK1) is a mitochondrial serine/threonine kinase that orchestrates ubiquitin-dependent mitophagy together with the E3 ligase Parkin. Both physiological and pathological conditions rapidly recruit PINK1, and timely PINK1 degradation in healthy mitochondria determines whether it supports or harms the cell. Thus, the tight regulation of PINK1 balances its negative effects. In this context, introducing physical exercise as one of the strategies can fine-tune PINK1/Parkin path