Evaluating the Efficacy of Dexmedetomidine as an Adjunct to Local Anesthetics in Adductor Canal Blocks for Adult Patients Undergoing Primary Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.

= .05). Time to first rescue analgesia increased by 1.54 hours, and ambulation outcomes consistently showed improvement in the dexmedetomidine group. This analysis supports the use of dexmedetomidine as an adjunct for ACB in TKA. However, significant heterogeneity among studies limits applicability of this analysis's findings. Clinicians are advised to consider this when making practice decisions.