Computational and familial phenotyping of impulsive decision-making in substance use disorders: similarities and differences between opioid and stimulant use disorders

Impulsive decision-making is strongly associated with substance use disorders (SUD). Using computational modeling, we investigated similarities and differences in decision-making profiles between stimulant and opioid users. Additionally, we used a sibling comparison design to determine if impulsive decision-making could serve as a computational marker of familial liability for addiction. Participants included individuals with “pure” SUD (opioids: N=157, stimulants: N=140), healthy controls (N=24