Hypoxic preconditioning restores the regenerative potential of aged adipose tissue derived mesenchymal stem cells

BACKGROUND Mesenchymal stem cells (MSCs) hold great promise for aesthetic dermatology due to their self-renewal, multipotency, and paracrine effects. However, MSCs derived from aged donors exhibit limited therapeutic efficacy in autologous applications due to their impaired regenerative potential. Hypoxic preconditioning has been explored as an effective strategy to improve the potential of stem cells. In the current study, we aim to prime cultured aged adipose tissue derived MSCs (ADMSCs) under