Hypoxia-inducible factor-1α/β-catenin axis: A conserved regulatory hub for enhancing stem cell function in tissue regeneration

This article provides an in-depth commentary on the study by Wang et al , which elucidates that the hypoxia-inducible factor-1α (HIF-1α)/β-catenin axis serves as a core hub regulating the function of peripheral blood mesenchymal stem cells (PBMSCs) under hypoxic conditions. The research confirms that in a hypoxic environment, HIF-1α acts as an upstream regulator by directly binding to and activating the transcription of β-catenin, a relationship that is unidirectional and irreversible. This axis