Hypoxia-preconditioned mesenchymal stem cell-derived exosomes attenuate myocardial ischemia/reperfusion injury by miR-29b-3p via PINK1/Parkin-mediated mitophagy
Wen Wen·Zheng Zhang·Yong Wang·Xiao-jiong Lu·Chao Yang·Shuanghui Chen·Jin Zhi-tao·Ming-Yue Qu·Jing-Yu Deng·Chen-Xi Liu
BACKGROUND Accumulating studies suggest that mesenchymal stem cell (MSC)-derived extracellular vesicles mitigate myocardial injury by modulating intercellular communication pathways. Notably, exosomes from hypoxia-preconditioned MSCs (HPC-Exo) demonstrate superior therapeutic efficacy in ischemic heart disease compared with those from normoxic MSCs although the underlying molecular mechanisms remain largely unclear. AIM To investigate the cardioprotective effects of HPC-Exo on myocardial ischemi